Mimestream is a native Mac email client made specifically for Gmail. It uses the Gmail API, so labels, filters, inbox categories, and search work the way they do in Gmail.

Key features:

Triage with Gmail inbox categories, color-coded labels, and server-side filters you can manage in the app.
Add all your Gmail accounts, keep them in separate profiles, or view them in a unified inbox.
Respond to calendar invitations while seeing your Google or Apple calendars alongside them.
Compose from Gmail aliases, use templates with fillable variables, and undo send with Command-Z.
Block trackers from more than 75 common services.
Set working hours and Focus filters to control notifications per account.

Mimestream keeps your data and tokens on your Mac and connects straight to the Gmail API. It requires macOS 12 Monterey or newer, is built for Apple silicon, and is sold directly rather than on the App Store. After a 14-day free trial with no credit card, the Individual plan costs $49.99 a year for up to five devices, with sharing for immediate family included.